What Is Preimplantation Genetic Testing For Aneuploidies (PGT-A)?
An embryo that appears healthy can contain chromosomal abnormalities. Preimplantation Genetic Testing for Aneuploidies provides information regarding the chromosomal health of the embryo. PGT-A can greatly enhance the chance of selecting the healthiest embryo, increasing the likelihood of a healthy pregnancy.
Patient Benefits of PGT-A
- High implantation and pregnancy rates (about 60%) and extremely low miscarriage rates (>10%)
- Enhanced confidence in single embryo transfer stemming from embryologist identifying chromosomally normal embryos that have the highest chance of implantation
- Safer IVF stimulation cycles that avoid hyper stimulation syndrome almost 100% of the time
- Enhanced fetal growth and pregnancy outcome with frozen embryo transfer
- The ability to identify and freeze healthy embryos for fertility preservation for future pregnancy wishes
- Provides credible information for patients considering donor egg or embryo adoption in situations where no embryos are chromosomally normal (typical in older patients)
IVF For ME Success Rates (Jan. 2010 – Dec. 2015)
|Age at Time of Retrieval||All Ages||<30||30-34||35-39||>39|
|Number of Thaws/Transfers||415||41||169||165||40|
|Percent Embryo Survival||99.1%||100%||98.9%||98.8%||100%|
|Ongoing Clinical Pregnancy Rate||59.2%||61%||61%||57.3%||57.5%|
|Mean Embryos Transferred||1||1||1.1||1||1.1|
- IVF with PGT-A (IVF For ME) – Ages <30 61% 61%
- IVF without PGT-A (Traditional IVF) – Ages <30 49.6% 49.6%
- IVF with PGT-A (IVF For ME) – Ages <30 61% 61%
- IVF without PGT-A (Traditional IVF) – Ages <30 47.4% 47.4%
- IVF with PGT-A (IVF For ME) – Ages <30 57.3% 57.3%
- IVF without PGT-A (Traditional IVF) – Ages <30 30.9% 30.9%
- IVF with PGT-A (IVF For ME) – Ages >39 57.5% 57.5%
- IVF without PGT-A (Traditional IVF) – Ages >39 17.4% 17.4%
National averages published by SART are found here. RAD-specific statistics published by SART can be found here.
***A comparison of clinic success rates may not be meaningful because patient medical characteristics, treatment approaches, and entrance criteria for ART may vary from clinic to clinic.
***Source: 2015 SART Report, Final Cumulative Outcome Per Egg Retrieval Cycle
When To Consider PGT-A
We offer PGT-A to all IVF patients. Those interested in this testing will be counseled to consider whether PGT-A makes sense for them. Common indications for recommending PGT-A include:
- Maternal age over 34
- Paternal age over 40
- Unexplained infertility at any age
- Prior failed IVF without explanations
- Prior pregnancy losses
- Diminished ovarian reserve (i.e. low AMH, high FSH)
- PGT-A is included in our IVF For ME™ Program
Articles & Publications
Gateway to IVF Success: The ABSs of PGT-A – October 1, 2014
IVF has actually become more efficient over recent years, with the development of newer and better lab culture conditions. Exciting research developments exploring genes and DNA have yielded a perfect collaboration between IVF centers and genetics experts. Dr. Feinberg touches on the importance of incorporating PGT-A into current IVF treatments.
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Preimplantation genetic testing for aneuploidies (PGT-A) is a tool used to optimize the efficiency of IVF, increasing the likelihood of a successful pregnancy.
PGT-M and PGT-SR
Preimplantation genetic testing for monogenic/single gene defects (PGT-M) and (PGT-SR) are tests that help evaluate embryos for genetic risk factors.
IVF Success Rates
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4735 Ogletown-Stanton Road
Medical Arts Pavilion 2
Newark, DE 19713
Silverside Medical Center
2700 Silverside Road, Suite 2A
Wilmington, DE 19810
Eden Hill Medical Center
200 Banning Street, Suite 240
Dover, DE 19904
Phone: (302) 602-8822
Fax: (302) 602-8832