Fertility centers are using new techniques to determine embryo health of an embryo before transfer into the uterus during IVF. Two of these screening tools, pre-implantation genetic screening (PGS) and time-lapse imaging, are routinely used at RADfertility.
Many failed IVF cycles and early pregnancy losses can be attributed to unknowingly transfer embryos with chromosomal abnormalities. However, chromosomal abnormalities can’t be observed during embryo culture in the laboratory. PGS is a tool used to identify whether an embryo has a full complement of 46 chromosomes prior to transfer.
The EmbryoScope® takes images every 10 – 15 minutes, giving embryologists the full picture of an embryo’s development, rather than just snapshots at key points.
RADfertility uses time-lapse imaging in the EmbryoScope®, a combination incubator, microscope and time-lapse camera. The EmbryoScope® takes images every 10 – 15 minutes, giving embryologists the full picture of an embryo’s development, rather than just snapshots at key points.
Both PGS and EmbryoScope® time-lapse imaging are tools to help RADfertility achieve high pregnancy rates with single embryo transfer (SET). However, some critics note there is insufficient published data to recommend either technique.
From Our Expert, Dr. Ronald Feinberg
“PGS and the EmbryoScope® are powerful tools to help achieve pregnancy at RADfertility.”
Our philosophy at RADfertility aligns very closely with our colleague Dr. Richard Scott at RMA-NJ, who is featured in this New York Times article. We believe every patient with infertility should be able to pursue IVF along with technologies such as PGS and EmbryoScope® culture, with single embryo transfer (SET) as the only acceptable standard of care.
There is a strong argument in choosing PGS for an IVF cycle. The transfer of a normal-appearing blastocyst that also tested normal using PGS has a very predictable rate of normal implantation—50% to 60%—in women of all ages, with a miscarriage rate of less than 10%.
Although all women can produce embryos with chromosomal problems, abnormalities increase with maternal age. Therefore, PGS’s benefits are most pronounced when maternal age is 33 or older. A younger woman benefits if fertility factors such as guarded ovarian reserve and/or a prior history of pregnancy loss are present.
The best chance for achieving a successful and healthy pregnancy is with SET. The increased chance of achieving pregnancy when two or more embryos are transferred is minimal and not justified as acceptable IVF care. Twin pregnancies cause both maternal and fetal health problems and significantly increased short-term and long-term health care costs.
A major concern for couples interested in PGS is cost. With PGS, we can usually achieve a healthy pregnancy quicker than IVF alone, while also avoiding a failed embryo transfer or miscarriage. Repeated transfer costs are not only expensive; the emotional cost of a failed transfer or pregnancy loss is immeasurable.
At RADfertility, we offer two packages to address PGS’s cost barrier. Patients can opt for PGS right away, or defer testing until the future, if it becomes necessary. This second approach is called, “Biopsy and Hold,” but RADfertility will be introducing a more patient-friendly program called TinyTEST (TEST = TrophEctoderm Storage) in the near future. TinyTEST will defer half the expense of PGS testing until actually needed.
PGS has limitations. Because only two to three cells are biopsied and tested from a blastocyst that typically contains 150 to 200 cells, those cells may not truly tell us the actual chromosome status of the entire embryo. This limitation is due to a biological phenomenon known as mosaicism, when cells from different regions of a developing embryo might not have the same chromosomal make-up.
At this time, we do not know the true rate of mosaicism within human blastocysts, and it is difficult to determine the false positive and negative rates from PGS. Researchers are working to estimate the mosaicism rate, and EmbryoScope® data might help us better identify mosaic embryos.
At RADfertility, we believe combining PGS and EmbryoScope® morphokinetic data will help optimize embryo selection. We are currently collecting and analyzing data from our patients who have opted for both PGS and EmbryoScope® culture. It is possible a subset of embryos with normal chromosomes and excellent EmbryoScope® developmental landmarks will successfully implant 70% to 80% of the time, or greater. Stay tuned!
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"I feel so lucky to have found RADfertility. I tried two other clinics before I expanded my search and found RADfertility. I drive an hour each way to go to them but I don’t regret a thing. They are so caring and so professional. Every time I message them they respond quickly. Every time I see them they have a friendly smile and warm welcome. They explain everything so well and I never feel lost in the process as I did elsewhere. They also took the time to figure out what was wrong. Other clinics threw up their hands, said 'I don’t know' and pushed me to try IVF."
"Dr. Feinberg and the entire staff at RADfertility are absolutely amazing. The receptionists, coordinators, nurses, and lab staff are compassionate, caring, and straight forward. I’ve had a 12-year infertility journey and I’ve tried other clinics but RADfertility was the only one I felt at ease with. They answered any questions that I had and were there any time I needed them. My coordinator, Amy, was the absolute best and always had my back. Dr. Feinberg’s dedication to his patients is incredible. You are not just a number there, you are a person with individualized needs and care."
"My journey with RADfertility and Dr. McGuirk started when my husband and I were trying to conceive and were having difficulty. We went to RADfertility, where we met Dr. McGuirk. I always say she changed my life and 'fixed' me. Dr. McGuirk is always learning more about endometriosis and how to help her patients. She’s brilliant and truly cares for you! I’m eternally grateful to her and everyone at RADfertility for their unwavering support, love, and care."
"Every step of our journey was tailored to us. We were treated so respectfully. Every detail was clearly explained and we felt so comfortable. Rhonda Wright was a Godsend and inspiring. I highly recommend this place! I cried when my weekly appointments were done and I 'graduated.'"
"The day I met Dr. Neithardt I knew she was the perfect doctor for me. Dr. Neithardt was so compassionate every step of the way. She held my hand, she hugged away tears, and continued to give me hope. There are not enough 'thank you's' in the world for Dr. Neithardt and the whole RADfertility team who will forever have a special place in my heart."
"RADfertility's staff has heart and provided me with exceptional health care. I knew I was in good hands and felt like we were in this together. The doctors and nursing staff always answered all of my questions and provided thorough information about all of my options. I am so fortunate and appreciative of the care that I received at RADfertility. They go above and beyond."
"I cannot begin to explain how wonderful RADfertility is. We were frustrated with trying to start a family and it not working for us. The entire team of doctors and nurses made us feel comfortable and hopeful that we would be parents. We experienced so many ups and downs but we never felt like we were on our IVF journey alone, we had our RADfertility team every step of the way. If you're looking for a supportive team on the IVF journey, look no further. RADfertility is the absolute best."
"Dr. Schillings always kept us informed and never gave up on us. She always explained our options and risks with each procedure. She called us personally when there were any issues or sensitive subjects to cover. Dr. Schillings was the first doctor that had answers for us and wanted to help us have our miracle baby!"
4735 Ogletown-Stanton Road
Medical Arts Pavilion 2
Newark, DE 19713
Silverside Medical Center
2700 Silverside Road, Suite 2A
Wilmington, DE 19810
Eden Hill Medical Center
200 Banning Street, Suite 240
Dover, DE 19904
Phone: (302) 602-8822
Fax: (302) 602-8832